Caudatin induced ubiquitin (Ub)-dependent glucocorticoid receptor (GR) degradation and blocked subsequent Of course-connected protein (YAP) nuclear accumulation and concentrate on gene transcription signals in BCSCs. These final results clearly show that the GR/YAP signaling pathway regulates BCSC formation and that caudatin could possibly be a pos

We recently reported the development of a novel inhibitor of Rho-mediated gene transcription (1, CCG-203971) that is efficacious in multiple animal versions of acute fibrosis, which include scleroderma, when supplied intraperitoneally. The modest in vivo potency and poor pharmacokinetics (PK) of this lead, nevertheless, ensure it is unsuitable for

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